Table 1 Associations of Aβ status with longitudinal plasma biomarker levels in BioFINDER-1 and WRAP

From: Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring

 

BioFINDER-1 Cognitively unimpaireda

BioFINDER-1 Mild cognitive impairmenta

WRAP Cognitively unimpairedb

Plasma biomarkers

Time × Aβ interaction β estimate (P value)

p-tau231

−0.002 (0.946)

−0.063 (0.437)

−0.001 (0.951)

p-tau217

0.249 (3.8 × 10−13)

0.270 (0.0005)

0.103 (5.4 × 10−8)

p-tau181

0.073 (0.066)

0.050 (0.384)

0.047 (0.036)

Aβ42/40

0.007 (0.841)

−0.076 (0.165)

−0.019 (0.345)

GFAP

0.028 (0.084)

0.113 (0.065)

0.023 (0.273)

NfL

0.035 (0.246)

0.084 (0.177)

−0.039 (0.273)

  1. β estimates and P values are from linear mixed effects models with the interaction between time and Aβ status as the independent variable, adjusted for age and sex. Two-sided P values were adjusted for multiple comparisons (n = 24, BioFINDER-1; n = 12, WRAP) using Benjamini–Hochberg FDR. Data tables with uncorrected P values are displayed in Supplementary Table 1.
  2. a Aβ42/40 data were available for 130 CU and 82 MCI; GFAP data were available for 124 CU and 82 MCI; NfL data were available for 125 CU and 82 MCI in BioFINDER-1. bData values for two participants were missing for p-tau231, p-tau181, Aβ42/40, GFAP and NfL in WRAP.
Back to article page