Table 2 Associations between longitudinal plasma biomarkers and longitudinal MMSE, mPACC and cortical thickness of the typical AD signature regions in Aβ-positive cognitively unimpaired participants in BioFINDER-1 and WRAP

From: Differential roles of Aβ42/40, p-tau231 and p-tau217 for Alzheimer’s trial selection and disease monitoring

 

BioFINDER-1

WRAP

MMSEa

mPACCa

Cortical thickness of the typical AD signature regionsb

MMSE c

mPACC c

Cortical thickness of the typical AD signature regions d

Plasma biomarkers

β estimate (P value)

p-tau231

−0.100 (0.215)

−0.022 (0.456)

−0.004 (0.229)

−0.030 (0.737)

−0.020 (0.427)

−0.002 (0.363)

p-tau217

−0.308 (0.0008)

−0.121 (0.0007)

−0.012 (4.1 × 10−5)

−0.135 (0.003)

−0.098 (9.0 × 10−7)

−0.005 (0.021)

p-tau181

−0.180 (0.058)

−0.044 (0.237)

−0.006 (0.051)

−0.075 (0.215)

−0.030 (0.317)

0.004 (0.148)

Aβ42/40

−0.010 (0.910)

0.032 (0.456)

0.002 (0.505)

−0.014 (0.754)

−0.032 (0.317)

−0.003 (0.245)

GFAP

−0.198 (0.058)

−0.054 (0.223)

−0.007 (0.040)

0.013 (0.754)

−0.007 (0.745)

−0.004 (0.051)

NfL

−0.194 (0.080)

−0.067 (0.220)

−0.004 (0.229)

−0.046 (0.527)

−0.024 (0.379)

−0.004 (0.034)

  1. β estimates and P values are from linear mixed effects models with the interaction between time and standardized plasma biomarker slopes (derived from subject-level linear regression models) as the independent variable, adjusted for age and sex; associations with cognition were also adjusted for years of education. Two-sided P values were adjusted for multiple comparisons within each variable (n = 6) using Benjamini–Hochberg FDR. Data tables with uncorrected P values are displayed in Supplementary Table 2.
  2. a Longitudinal MMSE, mPACC and plasma biomarker data were available for 57 (p-tau) and 49 (Aβ42/40, GFAP and NfL) Aβ-positive cognitively unimpaired BioFINDER-1 participants. b Longitudinal cortical thickness of the typical AD signature regions and plasma biomarker data were available for 56 (p-tau) and 48 (Aβ42/40, GFAP and NfL) Aβ-positive cognitively unimpaired BioFINDER-1 participants. c Longitudinal MMSE, mPACC and plasma biomarker data were available for 66 (p-tau217) and 65 (other biomarkers) Aβ-positive cognitively unimpaired participants in WRAP. dLongitudinal cortical thickness of the typical AD signature regions and plasma biomarker data were available for 65 Aβ-positive cognitively unimpaired participants in WRAP.
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