Extended Data Fig. 1: 4R CSF MTBR-tau assay is reproducible and stable in repeated lumbar punctures. | Nature Medicine

Extended Data Fig. 1: 4R CSF MTBR-tau assay is reproducible and stable in repeated lumbar punctures.

From: CSF tau microtubule-binding region identifies pathological changes in primary tauopathies

Extended Data Fig. 1: 4R CSF MTBR-tau assay is reproducible and stable in repeated lumbar punctures.

CSF MTBR-tau275/t-tau was measured in 25 participants (#01-#25) who had 3 to 5 repeated lumbar punctures within 4 months. FTLD-MAPT P301L (red, n = 2, #02, 03), symptomatic FTLD-MAPT R406W (blue, n = 1, #05), and pathologically-confirmed CBD (green, n = 2, #10 and #11) had decreased CSF MTBR-tau275/t-tau. Data are presented as mean values + /− SD. CBS: corticobasal syndrome, PSP-RS: progressive supranuclear palsy-Richardson’s syndrome, FTLD-MAPT: frontotemporal lobar degeneration with MAPT mutations.

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