Extended Data Fig. 6: Pre-boost serum neutralization of authentic WA1/2020 D614G, B.1.617.2, BA.1, and BA.5 viruses. | Nature Medicine

Extended Data Fig. 6: Pre-boost serum neutralization of authentic WA1/2020 D614G, B.1.617.2, BA.1, and BA.5 viruses.

From: Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice

Extended Data Fig. 6

Seven-week-old female K18-hACE2 mice were immunized with two sequential 0.25 μg doses of control mRNA or mRNA-1273 and then boosted 31 weeks later with PBS, 0.25 μg of control mRNA, or 0.25 μg mRNA-1273, mRNA-1273.214, or mRNA-1273.222. Neutralizing antibody responses against WA1/2020 D614G, B.1.617.2, BA.1, and BA.5 from serum immediately before boosting with the indicated vaccines. Neutralization curves (FRNT analysis) corresponding to individual mice are shown for the indicated immunizations. Serum are from two experiments, and each point represents the mean of two technical replicates. Primary data are provided as a Source Data file.

Source data

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