Extended Data Fig. 4: Comparison of serum neutralization using pseudotyped lentiviruses expressing Wuhan-1 D614G, BA.1, or BA.4/5 spike proteins. | Nature Medicine

Extended Data Fig. 4: Comparison of serum neutralization using pseudotyped lentiviruses expressing Wuhan-1 D614G, BA.1, or BA.4/5 spike proteins.

From: Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice

Extended Data Fig. 4

BALB/c mice were immunized with two sequential 1 μg doses of clinically representative versions of mRNA-1273, mRNA-1273.214 or mRNA-1273.222 vaccines. Serum neutralizing antibody responses against Wuhan-1 D614G, BA.1, and BA.4/5 were assessed two weeks after the second dose using pseudotyped lentiviruses. Average neutralization curves (n = 2) corresponding to individual mice are shown for the indicated vaccines. Primary data are provided as a Source Data file.

Source data

Back to article page