Fig. 1: Association of rs16906115 with ICB-associated irAEs and flux in lymphocytes.
From: IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
a, OR for developing irAEs requiring steroids before C5 of treatment, or ever, according to allele carriage of rs16906115 and treatment type, and all ICB. Whiskers represent 95% CI; two-sided Fisher exact test, n = 214 patients (98 sICB and 116 cICB). b, Pre-treatment versus first post-treatment lymphocyte count for patients receiving sICB, split by allele; two-sided Wilcoxon signed-rank test, n = 60 patients. c, Difference between pre-treatment and post-sICB treatment lymphocyte count by allele; one-sided Student’s t-test, n = 60 patients.
