Extended Data Fig. 4: Extended T cell data.

(a) Correlation of fold change in lymphocyte count measured on routine hospital bloods (as per Lymphocyte Stability) versus % change in cell subset as measured using flow-cytometry at the same timepoint. From left: right; % all T cells in PBMC, % T Effector Memory, % Naïve T cells; P value from Spearman rank test, dotted lines reflect fitted linear model, shaded area the 95% Confidence Interval, n = 40. (b) Correlation of CD8⁺ T cell expression of SH3BGRL2 versus the naïve marker CD27 in healthy donors (left facet) and patient samples (right facet); Spearman rank test, shaded area reflects 95% Confidence Interval of fitted linear model, P interaction with status <0.001, n = 67 controls, n = 326 patient C1/C2 samples. (c) GOBP pathway analysis of genes upregulated in CD8⁺ T cells in carriers of risk allele (as depicted in Fig. 4b), one-tailed hypergeometric test. (d) GOBP pathway analysis of genes anti-correlated in patient CD8⁺ T cells with increasing B cell IL7 expression from same blood samples, having corrected for rs16906115 status, one-tailed hypergeometric test. e) GOBP pathway analysis of genes anti-correlated in patient CD8⁺ T cells with increasing B cell IL7 expression in non-carriers of risk allele only, one-tailed hypergeometric test.