Extended Data Fig. 7: Delta-MA plot of anti-spike antibody titer effect on differential expression log (fold change).
From: Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
The x and y axes represent the average normalized gene expression and the differential expression log fold change (logFC) respectively. Each arrow shows a single DEG. The arrow colors indicate the anti-spike antibody titer dependent (red) and independent (blue) DEGs. The contours show the distribution of all logFC values before controlling for antibody titers. The effect of controlling for antibody titers on DEGs is shown by the arrows, with the arrow tail being the logFC before adjustment and the arrow head the logFC after adjustment. LogFC values in each panel are scaled such that the root mean square logFC before adjustment is equal to 1. a) Lung problems in plasma cells. b) Skin rash in plasma cells. c) Pneumonia in plasma cells. d) Sleep problems in plasma cells. e) Nausea/diarrhea/vomiting in plasma cells. f) Smell/taste problems in plasma cells. g) Anxiety/depression in memory B cells. h) Need Supplemental O2 in M1 macrophages.
