Extended Data Fig. 2: Relationship between acute anti-spike antibody titers and PASC with independent validation.
From: Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae
a) Association of acute anti-spike antibody titers to PASC symptoms in Mount Sinai cohort. The y axis is the symptom assessed, and the x axis is the P value (-log10) for the association of the anti-spike antibody titers to the symptoms (linear mixed model, 2-sided t-test). The shape indicates the class of anti-spike antibody tested, and the color indicates whether the association is significant (BH FDR ≤ 0.05). b) Independent dataset validation of the non-association of acute anti-spike antibody titers to PASC. The x axis is the anti-spike antibody class and the y axis the titer measured for antibodies against the S1 domain of the spike protein during acute COVID-19. Each point represents a subject (n = 134 subjects, 85 with PASC). The color indicates the presence and absence of PASC and is defined in the legend. Two sided Mann-Whitney test unadjusted P values are shown between groups indicated by the brackets. Distributions are shown using box-and-whiskers plots (thick bar, median; box, 25th to 75th percentile, whiskers reach to the largest/smallest observations within 1.5 box-heights of the box.
