Extended Data Fig. 8: WGS Circos plots with or without chromothripsis.
From: Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome
a, chromothripsis and kataegis in RS sample (Pt 42) with whole genome doubling. Circos plots showing structural variants (interchromosomal, blue; deletion, red; inversion, yellow; tandem duplication, green; long range, teal), allelic copy number (middle), rainfall plot with kataegis regions (red) and chromosomes (outside). Adjacent rainfall plots show kategis regions (C to G, red; C to T, yellow; C to A, teal) with corresponding allelic copy-number fragmentation. b, Circos plots from RS WGS samples showing structural variants (interchromosomal, blue; deletion, red; inversion, yellow; tandem duplication, green and long range, teal), allelic copy number (middle), rainfall plot with kataegis regions (red) and chromosomes (outside). SVs impacting known genes and translocation partners are labeled (Supplementary Table 7k).
