Extended Data Fig. 3: Phylogenetic reconstruction and somatic genomic alterations.
From: Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome
For each of the patient trios with WES data, the left panel shows the phylogenetic tree tracing the transformation history from CLL to RS. The magenta frame denotes the Richter clones. The middle top panel represents the subclonal composition inferred after clustering alterations with similar cancer cell fractions as previously reported4. The middle bottom panel indicates the timeline with RS and CLL sampling time and CLL therapeutic lines. (F, fludarabine; C, cyclophosphamide; R, rituximab; P, pentostatin; O/Ofa, ofatumumab; HDMP, high-dose methylprednisolone; A, alemtuzumab; Auto, autologous stem cell transplantation; CLB, chlorambucil; B, bendamustine; CHOP, cyclophosphamide, doxorubicin, vincristine, prednisone; ESHAP, etoposide, methylprednisolone, high-dose cytarabine, cisplatin; CHP, cyclophosphamide, doxorubicin, prednisone; Len, lenalidomide; Ob, obinutuzumab; idela; idelalisisb; D, dexamethasone; Adria, adriamycin). The right panel is composed of allelic fraction plots and allelic copy ratio plots showing clonal assignment of somatic copy-number events to CLL and RS clones. Cases with whole genome doubling in Extended Data Fig. 2 and clonal unrelated cases in Extended Data Fig. 3.
