Fig. 2: GWAS association analysis results for the total number of medication purchases in FinnGen.
From: Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases
a–c, Manhattan plots with two-sided P values of quantitative SAIGE mixed-model GWAS (n = 193,933) for the number of recorded purchases of drugs used in the treatment of hyperlipidemia (a), hypertension (b) and T2D (c). All loci containing one or more 95% CS are highlighted according to their previously reported related cardiometabolic associations; loci that have been previously associated with lipid-related traits (a), blood pressure-related traits (b) or blood glucose-related traits (c). The horizontal line signifies genome-wide significance (P < 5 × 10−8) without additional multiple testing correction.
