Extended Data Fig. 6: Suit features from the 9HPT task.

a. The average joint velocity of FA Patients and Controls during the 9HPT. The patients exhibit significantly slower velocities in all joints. Data are presented as mean ± standard deviation (n = 66 patient measurements and n = 18 control measurements) and ∗ represents p ≤ 0.05, ∗∗ is p ≤ 0.01 and ∗∗∗ is p ≤ 0.001 for Kruskal-Wallis one-way ANOVA. For the exact p-values of the ANOVA tests, see Supplementary Table 3. b. A PCA analysis of the angular velocities of the upper body showing the variability explained by having a different number of PCs. FA Patients require slightly more PCs to explain the variability in their movements than the Controls. Data are presented as mean ± standard deviation (n = 66 patient measurements and n = 18 control measurements). c. Our complexity metric showing an increased complexity in the FA Patients during the 9HPT. Data are presented as mean ± standard deviation (n = 66 patient measurements and n = 18 control measurements) and ∗ represents p ≤ 0.05, ∗∗ is p ≤ 0.01 and ∗∗∗ is p ≤ 0.001 for Kruskal-Wallis one-way ANOVA. For the exact p-values of the ANOVA tests, see Supplementary Table 3. d. A density plot generated using the kinematics of a typical FA patient during the 9HPT. The space was separated in 2x2x2cm blocks and the color of each block represents the time any joint (blue circles) spent in that area. Note that the color bar is on log10 scale. e. The workspace volume generated from the subjects’ density plot comparing the performance of FA Patients and Controls when performing the task with either hand. The plot shows a statistical difference between the two hands of FA Patients as well as a significant difference between the workspace volume generated by the FA Patients’ and Controls’ dominant hand. Data are presented as mean ± standard deviation (n = 66 patient measurements and n = 18 control measurements) and ∗ represents p ≤ 0.05, ∗∗ is p ≤ 0.01 and ∗∗∗ is p ≤ 0.001 for Kruskal-Wallis one-way ANOVA. For the exact p-values of the ANOVA tests, see Supplementary Table 3. f. The entropy of subjects’ density plots as a measure of their disorder showing that FA Patients have a lot more disorder than Controls across both hands. Data are presented as mean ± standard deviation (n = 66 patient measurements and n = 18 control measurements) and ∗ represents p ≤ 0.05, ∗∗ is p ≤ 0.01 and ∗∗∗ is p ≤ 0.001 for Kruskal-Wallis one-way ANOVA. For the exact p-values of the ANOVA tests, see Supplementary Table 3.