Extended Data Fig. 8: Logistic fit on joints' angular velocities.

a. A comparison between the probability density functions (PDF) of angular velocities for a typical joint (elbow flexion) showing a much wider spread in Controls than the FA Patients. This effect has been consistently observed across all upper body joints. The lines represent the mean and the shaded area around the lines represents the standard deviation in each population group. b. We fitted various parametric probability distributions on the joints’ angular velocities, and we found that a logistic distribution can provide the best fit in the data. c. A comparison between the variability (σ) of the logistic fit between the FA Patients and Controls after applying it on all upper body joints independently. The results reveal a much larger σ in some of the Controls’ joints meaning that they used a much wider range of velocities during the 9HPT than the FA Patients. Data are presented as mean ± standard deviation (n = 66 patient measurements and n = 18 control measurements) and ∗ represents p ≤ 0.05, ∗∗ is p ≤ 0.01 and ∗∗∗ is p ≤ 0.001 for Kruskal-Wallis one-way ANOVA. For the exact p-values of the ANOVA tests, see Supplementary Table 3.