Extended Data Fig. 4: CAR T Cell Concentrations Stratified by Response. | Nature Medicine

Extended Data Fig. 4: CAR T Cell Concentrations Stratified by Response.

From: Allogeneic BCMA-targeting CAR T cells in relapsed/refractory multiple myeloma: phase 1 UNIVERSAL trial interim results

Extended Data Fig. 4

(a) CAR T cell concentrations among ALLO-715 DL3 patients that received any fludarabine/cyclophosphamide/ALLO-647 (FCA) lymphodepletion are shown in responders and non-responders. Error bars show the interquartile range (IQR) for each data point. (b) CAR T cell concentrations among ALLO-715 DL3 patients that received any FCA lymphodepletion in non-responders and those with very good partial responses or better (VGPR+). Error bars show the IQR for each data point. (c) Box plot of vector copy number (VCN) responders and non-responders for all patients with assay results between days 1-28. The boxes represent the first quartile (Q1), median, and third quartile (Q3). The lower and the upper whiskers extend to the most extreme points within 1.5 × IQR of Q1 and Q3 respectively, where IQR = Q3-Q1. N = 20 independent study subjects (N = 6 non-responders; N = 14 responders).

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