Fig. 1: Flow chart for selecting the idiopathic POI cohort potentially attributable to genetic defects. | Nature Medicine

Fig. 1: Flow chart for selecting the idiopathic POI cohort potentially attributable to genetic defects.

From: Landscape of pathogenic mutations in premature ovarian insufficiency

Fig. 1: Flow chart for selecting the idiopathic POI cohort potentially attributable to genetic defects.The alternative text for this image may have been generated using AI.

A total of 1,790 patients with POI were recruited for the initial assessment, during which serum tests, pelvic ultrasounds and medical records were assessed for each participant. WES was performed in 1,030 patients who met inclusion criteria. *The inclusion criteria were based on 2016 ESHRE guidelines for POI. E2, estrogen.

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