Extended Data Fig. 5: Overview of mutations identified in known POI genes.
From: Landscape of pathogenic mutations in premature ovarian insufficiency
a, Distribution of pathogenic (P), likely pathogenic (LP), uncertain significance (VUS), likely benign (LB) and benign (B) variants across genes among all rare variants detected in known POI genes. b, Distribution of LoF, missense and other types (including in-frame indels and splice region) of all detected variants across genes. c, Distribution of LoF, missense and other types of P/LP variants across genes.
