Extended Data Fig. 1: NABUCCO study design.

Cohort 1 is shown at the top, cohort 2A and cohort 2B are shown at the bottom. Arrows correspond with timing of study procedures and apply to all cohorts. Peripheral blood mononuclear cells (PBMCs), urine and plasma samples were collected <24 hours prior to corresponding treatment cycle or radical surgery. C1/2/3: first, second and third treatment cycle.