Extended Data Fig. 2: Treatment, response and follow-up details for every patient treated in cohort 2A and 2B.

Swimmer plot with treatment and follow-up details for every patient in cohort 2A and 2B. Patients are organized per cohort and based on inclusion date. Time is relative to the date of first treatment of ipilimumab plus nivolumab (C1). Clinical TNM-stage prior to start of treatment is shown on the left side of the plot. Pathological TNM-stage after surgery is shown on the right side of the plot. Orange and green boxes represent treatment cycles administered. Black dots represent radical surgery. Open circles represent alternative surgery (transurethral resection bladder tumor and pelvic lymph node dissection). Black horizontal lines represent progression-free survival. Vertical lines indicate disease progression. Red horizontal lines represent survival after disease progression. Black cross indicates death. Two fatal surgery-related adverse events occurred within 90 days after surgery, both hemorrhage after an intra-operative complication. After extensive review, no relation with ipilimumab and/or nivolumab was established. Ipi: ipilimumab, Nivo: nivolumab, TURBT: transurethral resection of the bladder tumor, LND: lymph node dissection, C1: first treatment cycle.