Fig. 1: Tumor characteristics of the pairs of sBBCs included in the cohort.

a, Repartition of the association of the subtypes of breast cancers within a pair of sBBCs according to the concordance or the discordance status of the pair in the Curie cohort; tumor characteristics are based on the 302 pairs with concordance subtype available out of 313 pairs. The concordance refers to the status of both tumors within a pair of sBBCs regarding the subtype of breast cancer, either of the same subtype of breast cancer (tumor in concordant pair) or of different subtypes of breast cancers (tumor in discordant pair). b, Repartition of the association of the subtypes of breast cancers within a pair of sBBCs according to the concordance or the discordance status of the pair in the SEER cohort (8,367 patients with sBBCs, n = 16,734 tumors). c, Stromal TIL levels of the index tumor by subtype of breast cancer and by the concordance status of the pair it belongs to. Lower and upper bars represent the first and third quartiles, respectively; the medium bar is the median; and whiskers extend to 1.5 times the IQR. d, Intratumoral TIL levels of the index tumor by subtype of breast cancer and by the concordance status of the pair it belongs to. Lower and upper bars represent the first and third quartiles, respectively; the medium bar is the median; and whiskers extend to 1.5 times the IQR. e, pCR rates of the index tumor by subtype of breast cancer and by the concordance status of the pair it belongs to. f, Axillar pCR rates (proportion of patients with a post-NAC number of positive nodes >1 divided by the total number of patients) of the index tumor by subtype of breast cancer and by the concordance status of the pair it belongs to (n = 467 patients treated with NAC, representing 934 tumors). Statistical tests were Wilcoxon tests (c,d), Fisher tests (e) and chi-square tests (f). IT, intratumoral; Str, stromal.