Extended Data Fig. 9: DNA repair pathways.
From: Diagnostic classification of childhood cancer using multiscale transcriptomics
(a) Significantly enriched DNA repair pathways in pediatric cancers when compared to adult malignancies. The normalized enrichment scores were obtained with TMM-normalized expression pre-ranked GSEA. Only sets with one-sided hypergeometric test adjusted P value of less than 0.001 are shown. (b) Scatter plot showing values of median class entropy as a function of the DNA repair score (See Supplemental Methods for a definition). Adult classes are shown in blue, pediatric classes are shown in cyan. In red is the result of a linear regression, Pearson’s correlation coefficients and one-sided t-test P value are reported. The distributions of the DNA repair score for adult and pediatric samples are shown at the top, together with the two-sided Mann–Whitney U-test P value giving significance to their separation.
