Extended Data Fig. 4: Multivariate analysis of antibiotic exposure prior to CD19-targeted CAR-T cell infusion and PFS or OS. | Nature Medicine

Extended Data Fig. 4: Multivariate analysis of antibiotic exposure prior to CD19-targeted CAR-T cell infusion and PFS or OS.

From: A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

Extended Data Fig. 4: Multivariate analysis of antibiotic exposure prior to CD19-targeted CAR-T cell infusion and PFS or OS.

(a) The multivariate Cox model was adjusted for age (stratified by 65 years of age), ECOG (grade 0 and 1 vs. higher), country (Germany vs. US), LDH (normal vs. higher than ULN), CRP (normal vs. higher than 5 mg/dl), bulky disease (> 10 cm) and number of prior therapies (1-3 vs. 4-9). (b) The multivariate Cox model was adjusted for age (stratified by 65 years of age), ECOG (grade 0 and 1 vs. higher), country (Germany vs. US), LDH (normal vs. higher than ULN), CRP (normal vs. higher than 5 mg/dl), bulky disease (> 10 cm) and number of prior therapies (1-3 vs. 4-9). Error bars represent the low and high 95% confidence intervals (CI) of HR; *P < 0.05; **P < 0.01.

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