Fig. 5: Metabolic health of the metabolically obese group was improved during a healthy lifestyle intervention program. | Nature Medicine

Fig. 5: Metabolic health of the metabolically obese group was improved during a healthy lifestyle intervention program.

From: Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention

Fig. 5: Metabolic health of the metabolically obese group was improved during a healthy lifestyle intervention program.

a, Overview of the longitudinal analysis using omics-inferred BMI. b,c, Longitudinal change in the omics-inferred BMI within the overall cohort (b) or within each baseline BMI class (c). Average trajectory of each measured or omics-inferred BMI was independently estimated using LMM with random effects for each participant (Methods) in the overall cohort (b) or in each baseline BMI class-stratified group (c). d,e, Longitudinal change in MetBMI of the misclassified participants within the normal (d) or obese (e) BMI class. Average trajectory of each BMI or MetBMI was independently estimated using the above LMM with the baseline misclassification of BMI class against MetBMI class as additional fixed effects (Methods) in each baseline BMI class-stratified group. b–e, The dashed line corresponds to the baseline value of each estimate. Data: mean with 95% confidence interval; n = 608 (b), 222 (c, Normal), 185 (c, Overweight), 196 (c, Obese), 137 (d, Matched), 85 (d, Mismatched), 139 (e, Matched) or 57 (e, Mismatched) participants.

Back to article page