Extended Data Fig. 9: Tumor board discussions of cases with discrepant classification.

Details of tumor board discussions of tumors with discrepant classification by random forest (RF)-based and t-SNE-based DNA methylation class assignment (as in Fig. 3c and Supplementary Fig. 8; upper two rows) and WHO-based tumor type (third row). Colors in rows 1–3 correspond to tumor types and classes as indicated in Fig. 1 and Extended Data Fig. 1. Tumor board participants and availability of additional information (gene panel sequencing, reference radiology) is indicated by black boxes as well as compatibility with DNA methylation- and WHO-based tumor classification. Levels of discrepancy (corresponding to Fig. 3c and Supplementary Fig. 8) and tumor board consensus are categorized in bottom rows. See Supplementary Table 1 for underlying data.