Extended Data Fig. 4: Age-stratified PGSPSA associations.
From: Genetically adjusted PSA levels for prostate cancer screening
Performance of the genome-wide PGSPSA developed using the PRS-CSx algorithm was evaluated in the two cancer prevention trials: a, Prostate Cancer Prevention Trial (PCPT) and b, Selenium and Vitamin E Cancer Prevention Trial (SELECT). Crossbars visualize the effect estimates (β) and corresponding 95% confidence intervals per standard deviation (SD) increase in the standardized PGSPSA. Associations between PGSPSA and baseline log(PSA) were estimated in the pooled sample and stratified by age group. All p-valued are two-sided and derived from linear regression models adjusted for age at baseline, top 10 population-specific genetic ancestry principial components, and proportions of African and East Asian genetic ancestry.
