Extended Data Fig. 1: Comparisons of (a) iTRE vs CR, and (b) iTRE + CR vs SC for joint change in postprandial glucose (mg/dL/min) and HbA1c (%).

Points indicate prior (blue), posterior (red) and observed means (black). The ellipses indicate 95% central prior (blue) and posterior (red) probabilities. We note that our prior belief was for a correlation of 0.7 in change of the two outcomes, which was not observed. iTRE, intermittent time-restricted diet at 70% of calculated energy requirements; CR, calorie restriction diet at 70% of calculated daily energy requirements; SC: standard care diet.