Extended Data Fig. 8: Morphological assessment of microglia in RELN-COLBOS and APOECh protected cases.
From: Resilience to autosomal dominant Alzheimer’s disease in a Reelin-COLBOS heterozygous man
a, Representative pictures of ionized calcium binding adaptor molecule1 (IBA1) stained microglia in frontal cortex, hippocampus, and occipital cortex from both, PSEN1 E280A RELN-COLBOS case and the PSEN1 E280A APOECh homozygous case. Bar, 50 μm. b, c, Violin plots for size and circularity assessment in RELN-COLBOS and APOECh cases. The RELN-COLBOS showed significantly larger microglia in frontal cortex (FC, number of particles, np = 45679) and hippocampus (Hip, np = 21407), and smaller microglia in the occipital cortex (OC, np = 22365). Microglial circularity was higher in the APOECh case in all areas (np values for APOECh: FC = 18537, Hip = 14265, OC = 23845). P ≤ 0.001 ****. Two-sided Student’s test was used for analysis.
