Fig. 4: Tumor mutational burden, immunoediting score, TCR clonality and survival.

a, Nonsynonymous mutation frequency per mega base (Mb) by ICR cluster. P value was calculated using unpaired, two-sided Student’s t-test. Center line, box limits and whiskers represent the median, interquartile range and 1.5× interquartile range, respectively. b, Kaplan–Meier OS curve for the combination of ICR cluster and mutational load category. Mutational load high is defined as nonsynonymous mutation frequency of >12 per Mb. Overall P value is calculated by log-rank test. c, Scatter-plot of ICR score by genetic immunoediting (GIE) value for ICR-high and ICR-low samples. Number of samples in each quadrant is indicated in the graph. Gray area delineates ICR scores from 5–9. d, Kaplan–Meier for OS by IES. Censor points are indicated by vertical lines and corresponding table of number of patients at risk in each group is included below the Kaplan–Meier plot. Overall P value is calculated by log-rank test. e, Violin plot of IES by productive TCR clonality (immunoSEQ) (left) and MiXCR-derived TCR clonality (right). Spearman correlation statistics are indicated above each plot. Significance within ICR low and high is indicated. Center line, box limits and whiskers represent the median, interquartile range and 1.5× interquartile range, respectively. P values are two-sided, n reflects the independent number of samples.