Extended Data Fig. 6: Absolute risk and HRR of developing anxiety. | Nature Medicine

Extended Data Fig. 6: Absolute risk and HRR of developing anxiety.

From: Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

Extended Data Fig. 6: Absolute risk and HRR of developing anxiety.The alternative text for this image may have been generated using AI.

Left subpanels: Absolute risk (95%-CI) of developing anxiety since first depression episode for three groups of PRS deciles (1st, 2nd-to-9th and 10th) among 25124 depression cases with/without (NDEPwANX = 3010, NDEPwoANX = 22114) anxiety. The absolute risk (95%-CI) of anxiety in light blue for the iPSYCH2015 subcohort (random population sample) excluding all depression cases, aligned to match the endpoint for the depression-cohort. Right subpanels: HRRs (95%) for 1st and 10th decile using 2nd-to-9th decile as reference (see Supplementary Table 13a) in colors matching the absolute risks curves. For deciles of (a) Depression DEP-PRS, (b) Anxiety ANX-PRS, (c) Bipolar disorder BP-PRS, (d) Schizophrenia SZ-PRS, (e) ADHD-PRS, (f) Autism ASD-PRS, (g) Neuroticism PRS, (h) Substance Use SU-PRS, (i) Substance Use Disorder SUD-PRS and (j) sum of PRSs. The SUM-PRS was calculated by adding PRSs for multiple phenotypes weighted by log(OR) with the aim of optimizing prediction (see Methods for details). See Supplementary Fig. 20-1–20-2 and Supplementary Table 19b – 19c for sex-stratified analyses.

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