Extended Data Fig. 3: MvPRS analyses of depression cases with/without bipolar disorder (BP). | Nature Medicine

Extended Data Fig. 3: MvPRS analyses of depression cases with/without bipolar disorder (BP).

From: Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

Extended Data Fig. 3: MvPRS analyses of depression cases with/without bipolar disorder (BP).The alternative text for this image may have been generated using AI.

Depression-subphenotype is shown on the x-axis (NDEPwoBP = 29158, DEPwBP, N = 1460 and Nctrls = 38200). The slope (β) of the linear regression (95% CI) for each depression subphenotype is shown on the y axis. Significant difference between β for depression without/with an additional diagnosis is indicated with horizontal line with nominal two-sided P value above, that is the Wald test of equal group effect (See Supplementary Table 12d). Overall two-sided P value = 1.5 × 10−15. The polygenic risk scores analyzed are (a) PRS for depression (DEP-PRS), (b) PRS for anxiety (ANX-PRS), (c) PRS for bipolar disorder (BP-PRS), (d) PRS for schizophrenia (SZ-PRS), (e) PRS for ADHD (ADHD-PRS), (f) PRS for autism (ASD-PRS), (g) PRS for neuroticism (Neuroticism PRS), (h) PRS for substance use (SU-PRS), and (i) PRS for substance use disorder (SUD-PRS). See Supplementary Table 18e, S18f, Supplementary Fig. 19-1 and 19-2 for sex-stratified analyses.

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