Extended Data Table 1 Number of comorbid diagnoses among depression subtypes: single-episode and recurrent depression

From: Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses

  1. Number of comorbid diagnoses among depression subtypes: single-episode and recurrent depression. Numbers are after relatedness pruning / removal of ancestry outliers. Number in brackets are fraction of depression cases being comorbid with bipolar disorder (BP), schizophrenia (SZ), anxiety (ANX), autism (ASD), ADHD, substance use disorder (SUD) or having depression as the only diagnosis or being the fraction of depression cases that do not have bipolar disorder. Except for population sample where numbers in brackets indicate phenotype fractions in the population-based iPSYCH2015 sample. All numbers are without bipolar disorder except for the BP column. Whether recurrent depression was associated with increased comorbidity compared to single-episode depression was tested using logistic regression for each additional diagnosis while adjusting for age. Since the age-distribution for cases was skewed compared to controls individuals were grouped in age bins in five-year intervals to construct dummy variables for the age adjustment. Odds-Ratios (OR = log(β)) and nominal two-sided P values based on logistic regression z statistics are shown.
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