Extended Data Fig. 1: Impact of astrocyte reactivity in the association between Aβ-PET and plasma p-tau181 in a subset of individuals from MYHAT and Pittsburgh cohorts.

a, Robust locally weighted regressions show that plasma p-tau181 increases as a function of Aβ-PET only in Ast+ (n = 150). b, Linear regressions revealed an interaction between Aβ-PET and astrocyte reactivity status on p-tau181 levels (n = 150). The plots show regression line with their respective 95% confidence intervals. P-values were computed using linear regression models adjusted by age and sex. In addition, the Aβ-PET × astrocyte reactivity status interaction was also computed. Red lines and dots represent Ast+ and orange lines and dots represent Ast− individuals. c, Cohen’s d analysis accounting for age and sex shows the effect sizes of Aβ and Ast on plasma p-tau181 (n = 150). The error bars denote the 95% confidence intervals.