Extended Data Table 5 Associations between plasma p-tau and Aβ burden according to microglial activation (MA) status in the TRIAD cohort

From: Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

  1. Abbreviations: MA−: microglial activation negative; MA+: microglial activation positive; p-tau: phosphorylated tau. Covariates: age and sex. The effect of astrocyte reactivity in this subpopulation remained significant (Aβ burden × Astrocyte positivity status: β = 0.50, 95% CI = 0.15–0.85; t-value = 2.87; p-value = 0.006). P-values were computed using linear regression models adjusted by age, sex and cohort (when appropriate) for individuals classifies as MA− and MA+. In addition, the Aβ burden × microglial activation status interaction was also computed.
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