Extended Data Fig. 6: Associations between all CSF biomarkers and MMSE.
From: CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
In BioFINDER-2 cohort (A), orange dots represent MCI+ participants whereas in the Kinght-ADRC cohort (B), represent very mild AD. Linear regression models, adjusting for age, sex and years of education were used to obtain standardized β and p-values shown in the plots. *, p < 0.50; **, p < 0.010; ***, p <0.001. Abbreviations: AD + , Alzheimer’s disease dementia amyloid positive; CSF, cerebrospinal fluid; CU-, cognitively unimpaired amyloid negative; CU + , cognitively unimpaired amyloid positive; MCI + , mild cognitive impairment amyloid positive; MMSE, Mini Mental State Examination; MTBR, microtubule binding region; PET, positron emission tomography, SD, standard deviation; SUVR, standardized uptake value ratio.
