Extended Data Table 4 Parsimonious models for predicting AD-related continuous measures

From: CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

  1. Partial R2 (pR2) for all predictors included in the parsimonious model were calculated in a multivariable linear regression model with amyloid-PET, tau-PET and MMSE continuous measures as outcomes, respectively. R2 and AICc for the whole model are also included in the table. Parsimonious model for each outcome and cohort were obtained with the optimal combination of CSF biomarkers and demographics (age and/or sex and/or education) assessed using a LASSO regression. Non-AD cases were excluded from BioFINDER-2 cohort for the MMSE analyses. Amyloid-positive participants were selected based on CSF Aβ42/40 previously validated cutoffs (CSF Aβ42/40 < 0.08 in BioFINDER-2 and CSF Aβ42/40 < 0.0673 in Knight ADRC).
  2. Abbreviations: Aβ, amyloid; AICc, corrected Akaike information criterion; CSF, cerebrospinal fluid; LASSO, least absolute shrinkage and selection operator; MMSE, Mini-Mental State Examination; MTBR, microtubule binding region; PET, positron emission tomography.
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