Extended Data Fig. 8: Expansion and persistence of gavo-cel in peripheral blood. | Nature Medicine

Extended Data Fig. 8: Expansion and persistence of gavo-cel in peripheral blood.

From: Mesothelin-targeting T cell receptor fusion construct cell therapy in refractory solid tumors: phase 1/2 trial interim results

Extended Data Fig. 8: Expansion and persistence of gavo-cel in peripheral blood.

a, Kinetics of gavo-cel T cell expansion and persistence in peripheral blood by qPCR-based detection of specific TRuC-encoding proviral sequences in genomic DNA. Patients are grouped by dose level. b, Gavo-cel expansion and persistence over time in peripheral blood and at specific time points in cancerous tissues. Pink squares denote gavo-cel transgene level in serosal effusion; green circle denotes gavo-cel transgene level in peritoneal mesothelioma nodule. *Partial response by local investigator assessment.

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