Extended Data Table 1 Pregnancies with a cfDNA sample at PE diagnosis
From: Cell-free DNA methylome analysis for early preeclampsia prediction
- Preeclampsia (PE); extended prior risk model (ePRM), Body-mass index (BMI). The body-mass index is the weight in kilograms divided by the square of the height in meters. Fetal fraction was estimated using the SeqFF method as described by Kim et al.46 for samples that underwent shallow whole-genome cfDNA sequencing. Small-for-gestational-age was defined as an infant with a birthweight below the 10th centile for their gestational age at delivery. ePRM PE risk assessment: Risk calculation of delivery with PE < 34 weeks gestation based on the extended prior model determined from maternal demographic characteristics, medical history and pregnancy as described by Wright and colleagues7. Normal continuous data is reported as mean ± s.d. and P values are calculated according to Welch Two Sample t-test (two-sided). Non-normal continuous data are reported as Median [IQR] and P values are calculated according to (two-sided) Wilcoxon rank sum test. Shapiro-Wilk normality test was used to test for normality. Categorical data are reported as absolute frequencies with the corresponding relative frequencies in brackets and two-sided P values are calculated using the chi-square test or Fisher’s exact test, as appropriate. P values ≤ 0.05 in bold. No corrections were made for multiple comparisons. † denotes that missing values were omitted from reported values for a given feature.
