Fig. 2: Cumulative incidence of subsequent breast cancer in female 5-year childhood cancer survivors by cumulative doxorubicin dose, stratified by chest radiotherapy status (primary cancer diagnosis year 1946–2012). | Nature Medicine

Fig. 2: Cumulative incidence of subsequent breast cancer in female 5-year childhood cancer survivors by cumulative doxorubicin dose, stratified by chest radiotherapy status (primary cancer diagnosis year 1946–2012).

From: Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer

Fig. 2: Cumulative incidence of subsequent breast cancer in female 5-year childhood cancer survivors by cumulative doxorubicin dose, stratified by chest radiotherapy status (primary cancer diagnosis year 1946–2012).

Stratification by a, chest radiotherapy status; b, Mantle field; c, Mediastinal field; d, TBI/whole lung field; e, Other chest field. The SCCSS was excluded from cumulative incidence analyses due to the case–cohort design. The cumulative incidence figures represent univariable comparisons. Multivariable Cox regression results for the cumulative doxorubicin dose categories presented in this figure are shown in Extended Data Table 4. No., number; RT, radiotherapy.

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