Fig. 2: High fibrinogen is linked with objective and subjective cognitive deficits.

a,b, A first dimension of covariation links high fibrinogen with relatively low CRP to higher C-PSQ at 6 and 12 months (signs of subjective cognitive deficits) and lower MoCA at 6 and 12 months (signs of objective cognitive deficits). P values are derived from permutation tests, two-sided and not corrected for multiple comparisons. c–h, Distribution of different variables between the top half and the bottom half of the cohort along this first dimension (n = 768, 1,777, 1,837, 626, 1,502 and 584 individual participants, respectively). The center of the boxes represents the median, their bounds represent the 25th and 75th centiles and the lower and upper ends of whiskers represent the smallest/largest values, no further than 1.5 × IQR from the box-plot respective end. Distribution of all variables investigated is found in Supplementary Figs. 4–6. NS, P > 0.05.