Fig. 4: Mediation by other clinical features.

Mediation of the associations captured in the first and second dimensions of covariation by scales representing other aspects of health at 6 months after COVID-19. The names of the scales are reported in brackets. P values were estimated using nonparametric bootstrap with 1,000 repetitions and are two-sided and not adjusted for multiple comparisons: ***P < 0.001. For the second dimension, the P value for fatigue was 0.004 and for shortness of breath it was <0.001 (below the minimum threshold detectable with 1,000 repetitions). FACIT, Functional Assessment of Chronic Illness Therapy; BPI, Brief Pain Inventory; SARC-F, Sarcopenia screen; ISWT, Incremental Shuttle Walk Test; GPPAQ, General Practice Physical Activity Questionnaire; SPPB, Short Physical Performance Battery; PHQ-9, Patient Health Questionnaire; PTSD, post-traumatic stress disorder; PCL-5, PTSD Checklist; GAD-7, Generalized Anxiety Disorder scale; PAI, Physical Activity Index.