Table 1 Baseline characteristics for the whole cohort and the sub-cohorts that score in the top and bottom half along the first and second dimensions of covariation discovered in this study

From: Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

Cohort

Whole cohort

Bottom half on first dimension

Top half on first dimension

Bottom half on second dimension

Top half on second dimension

Number

1,837

919

918

919

918

Demographics

Age, mean (s.d.)

57.9 (12.4)

58.0 (12.7)

57.8 (12.2)

57.8 (12.6)

58.0 (12.3)

Sex, n (%)

 Female

673 (36.6)

330 (35.9)

343 (37.4)

316 (34.4)

357 (38.9)

 Male

1,060 (57.7)

540 (58.8)

520 (56.6)

553 (60.2)

507 (55.2)

 Missing

104 (5.7)

49 (5.3)

55 (6.0)

50 (5.4)

54 (5.9)

Race, n (%)

 White

1,385 (75.4)

689 (75.0)

696 (75.8)

689 (75.0)

696 (75.8)

 Mixed

26 (1.4)

16 (1.7)

10 (1.1)

14 (1.5)

12 (1.3)

 Asian

217 (11.8)

103 (11.2)

114 (12.4)

117 (12.7)

100 (10.9)

 Black

104 (5.7)

52 (5.7)

52 (5.7)

54 (5.9)

50 (5.4)

 Other

58 (3.2)

31 (3.4)

27 (2.9)

30 (3.3)

28 (3.1)

 Unknown

47 (2.6)

28 (3.0)

19 (2.1)

15 (1.6)

32 (3.5)

Education

 Primary school

40 (2.2)

18 (2.0)

22 (2.4)

17 (1.8)

23 (2.5)

 Secondary school

550 (29.9)

274 (29.8)

276 (30.1)

281 (30.6)

269 (29.3)

 Sixth-form college

237 (12.9)

117 (12.7)

120 (13.1)

114 (12.4)

123 (13.4)

 Vocational qualification

222 (12.1)

108 (11.8)

114 (12.4)

107 (11.6)

115 (12.5)

 Undergraduate university degree

301 (16.4)

150 (16.3)

151 (16.4)

160 (17.4)

141 (15.4)

 Postgraduate qualification

237 (12.9)

122 (13.3)

115 (12.5)

123 (13.4)

114 (12.4)

 Prefer not to say

51 (2.8)

25 (2.7)

26 (2.8)

24 (2.6)

27 (2.9)

 None

50 (2.7)

26 (2.8)

24 (2.6)

29 (3.2)

21 (2.3)

 Missing

149 (8.1)

79 (8.6)

70 (7.6)

64 (7.0)

85 (9.3)

Income, n (%)

 <£19,000

252 (13.7)

116 (12.6)

136 (14.8)

117 (12.7)

135 (14.7)

 £19,001–26,000

207 (11.3)

97 (10.6)

110 (12.0)

107 (11.6)

100 (10.9)

 £26,001–35,000

202 (11.0)

100 (10.9)

102 (11.1)

104 (11.3)

98 (10.7)

 £35,001–48,000

200 (10.9)

103 (11.2)

97 (10.6)

102 (11.1)

98 (10.7)

 >£48,001

439 (23.9)

224 (24.4)

215 (23.4)

227 (24.7)

212 (23.1)

 Prefer not to say

386 (21.0)

198 (21.5)

188 (20.5)

193 (21.0)

193 (21.0)

 Missing

151 (8.2)

81 (8.8)

70 (7.6)

69 (7.5)

82 (8.9)

Is married, n (%)

 Yes

1,034 (56.3)

517 (56.3)

517 (56.3)

523 (56.9)

511 (55.7)

 No

669 (36.4)

334 (36.3)

335 (36.5)

335 (36.5)

334 (36.4)

 Missing

134 (7.3)

68 (7.4)

66 (7.2)

61 (6.6)

73 (8.0)

English as the first language, n (%)

 Yes

1,469 (80.0)

734 (79.9)

735 (80.1)

733 (79.8)

736 (80.2)

 No

244 (13.3)

123 (13.4)

121 (13.2)

133 (14.5)

111 (12.1)

 Missing

124 (6.8)

62 (6.7)

62 (6.8)

53 (5.8)

71 (7.7)

Comorbidities, n (%)

 Cardiovascular condition

826 (45.0)

410 (44.6)

416 (45.3)

400 (43.5)

426 (46.4)

 History of cerebrovascular accident

79 (4.3)

37 (4.0)

42 (4.6)

35 (3.8)

44 (4.8)

 Dementia

<10

<10

<10

<10

<10

 Parkinson’s disease

<10

<10

<10

<10

<10

 Psychiatric or neurological condition

332 (18.1)

168 (18.3)

164 (17.9)

159 (17.3)

173 (18.8)

 ME/CFS/fibromyalgia/chronic pain

93 (5.1)

45 (4.9)

48 (5.2)

44 (4.8)

49 (5.3)

 Diabetes

366 (19.9)

179 (19.5)

187 (20.4)

173 (18.8)

193 (21.0)

 Respiratory condition

507 (27.6)

261 (28.4)

246 (26.8)

249 (27.1)

258 (28.1)

 Rheumatological condition

285 (15.5)

148 (16.1)

137 (14.9)

136 (14.8)

149 (16.2)

 Gastrointestinal condition

391 (21.3)

199 (21.7)

192 (20.9)

194 (21.1)

197 (21.5)

 Endocrine condition

147 (8.0)

71 (7.7)

76 (8.3)

74 (8.1)

73 (8.0)

 Chronic kidney disease

72 (3.9)

37 (4.0)

35 (3.8)

30 (3.3)

42 (4.6)

 History of cancer

134 (7.3)

66 (7.2)

68 (7.4)

67 (7.3)

67 (7.3)

 Chronic infectious disease

38 (2.1)

20 (2.2)

18 (2.0)

22 (2.4)

16 (1.7)

Follow-up

 Number at 6 months, n (%)

1,837 (100.0)

919 (100.0)

918 (100.0)

919 (100.0)

918 (100.0)

 Time at 6 months, median (IQR), days

176 (135–206)

176 (137–206)

177 (133–206)

177 (134–207)

175 (138–205)

 Number at 12 months, n (%)

626 (34.0)

308 (33.5)

318 (34.6)

310 (33.7)

316 (34.4)

 Time at 12 months, median (IQR), days

403 (375–426)

404 (376–426)

402 (374–428)

406 (376–427)

400 (374–426)

Diagnosis of COVID-19

 Positive PCR test, n (%)

1,553 (84.5)

795 (86.5)

758 (82.6)

795 (86.5)

758 (82.6)

 Undocumented method, n (%)

284 (15.5)

124 (13.5)

160 (17.4)

124 (13.5)

160 (17.4)

  1. IQR, interquartile range; ME, myalgic encephalomyelitis.