Extended Data Fig. 4: Additional information on PNPLA3 expression according to age and sex and PNPLA3 targetpathways in women from the Transcriptomic cohort. | Nature Medicine

Extended Data Fig. 4: Additional information on PNPLA3 expression according to age and sex and PNPLA3 targetpathways in women from the Transcriptomic cohort.

From: Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women

Extended Data Fig. 4

a) Hepatic PNPLA3 expression in patients in the Transcriptomic cohort stratified by sex and menopause status. In the box and whisker plots, the line in the middle of the box represents the medians, tops and bottoms of the boxes represent the 25th and 75th quartiles respectively, and the whiskers showed the 5th and 95th percentile; Kruskal-Wallis followed by Dunn’s post hoc test. b) Gene set enrichment analysis (GSEA) of pathways enriched in genes differentially expressed in women carrying PNPLA3 p.I148M variant; are considered only the terms with a p < 0.05.

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