Extended Data Fig. 4: Cytokine production of yeast-reactive CD4+ T cells. | Nature Medicine

Extended Data Fig. 4: Cytokine production of yeast-reactive CD4+ T cells.

From: Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn’s disease

Extended Data Fig. 4: Cytokine production of yeast-reactive CD4+ T cells.

(a) Proportion of IL-17A+IFN-γ+ cells reactive against the different fungal antigens. n indicates the number of individual donors specified below each group. (b) Proportion of IL-17A+IFN-γ+ cells in CD patients according to their ASCA status. n indicates the number of individual donors specified below each group. (c) Example plots for ex vivo cytokine production of S. cerevisiae-reactive Tmem following ARTE. Percentages of cytokine positive cells within CD154+ Tmem are indicated. (d) Cytokine production of C. tropicalis, C. albicans and M. restricta-reactive T cells in healthy donors and IBD patients. n indicates the number of individual donors specified below each group. Each symbol in (a, b, d) represents one individual donor, truncated violin plots with quartiles and range are shown in (b, d). Statistical differences: two-tailed Mann-Whitney test in (b); Kruskal-Wallis test with Dunn’s post hoc test in (d), only significant differences are shown.

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