Table 1 Baseline characteristics of study participants in the intent-to-treat analysis (n = 718)

From: Antimalarial artesunate–mefloquine versus praziquantel in African children with schistosomiasis: an open-label, randomized controlled trial

 

Total (n = 718)

AM (n = 360)

PZQ (n = 358)

Male gender

399 (55.6)

197 (54.7)

202 (56.4)

Female gender

319 (44.4)

163 (45.3)

156 (43.6)

Age (years), median (IQR)

9.00 (7.00 to 11.0)

9.00 (7.00 to 11.0)

9.00 (7.00 to 11.0)

Height (cm), median (IQR)

132 (123 to 141)

133 (123 to 142)

131 (122 to 140)

Weight (kg), median (IQR)

25.0 (21.0 to 31.0)

25.0 (21.0 to 31.0)

25.0 (21.0 to 30.0)

Schistosoma species

 Single S. haematobium infection

609 (84.8)

306 (85.0)

303 (84.6)

 Single S. mansoni infection

5 (0.70)

5 (1.39)

0 (0.00)

 Mixed infection

104 (14.5)

49 (13.6)

55 (15.4)

Schistosomiasis infection intensitya

S. haematobium

 Light (<50 eggs per 10 ml urine)

585 (81.5)

294 (81.7)

291 (81.3)

 Heavy (>50 eggs per 10 ml urine)

128 (17.8)

61 (16.9)

67 (18.7)

S. mansoni

 Light (1–99 eggs per gram stool)

87 (12.1)

44 (12.2)

43 (12.0)

 Moderate (100–399 eggs per gram stool)

19 (2.65)

9 (2.50)

10 (2.79)

Heavy (>400 eggs per gram stool)

3 (0.42)

1 (0.28)

2 (0.56)

Clinical symptoms

 None

615 (85.7)

307 (85.28)

308 (86.03)

 Abdominal pain

16 (2.23)

11 (3.06)

5 (1.40)

 Blood in stool

14 (1.95)

7 (1.94)

7 (1.96)

 Painful micturition

8 (1.11)

4 (1.11)

4 (1.12)

 Gross hematuria

65 (9.05)

31 (8.61)

34 (9.50)

Indirect morbidity markers

 Presence of anemia (hemoglobin level <11.5 g dl−1)

229 (31.9)

112 (31.1)

117 (32.7)

 Hemoglobin level (g dl−1), median (IQR)

12.0 (11.3 to 12.7)

12.0 (11.3 to 12.8)

12.0 (11.3 to 12.7)

 Presence of fecal occult blood (positive or trace)

166/682 (24.3)

79/338 (23.4)

87/344 (25.3)

 Presence of microhematuria (1+ to 4+ on urine dipstick)

369/661 (55.8)

183/339 (54.0)

186/322 (57.8)

 Presence of proteinuria (1+ to 3+ on urine dipstick)

294/661 (44.5)

146/339 (43.1)

148/322 (46.0)

Abdominal ultrasound findings

 Uni- and/or bilateral ureteral abnormalities (partial dilatation)

5/527 (1.0)

2/267 (0.8)

3/258 (1.2)

 Focal/multifocal bladder abnormalities (wall irregularities or thickness, or masses >10 mm)

24/537 (4.5)

7/274 (2.6)

17/259 (6.6)

 Liver abnormal patterns (C to F)b

9/531 (1.7)

4/271 (1.5)

5/260 (1.9)

  1. aThe intensity of infection for the microscopy results is categorized according to WHO recommendations9.
  2. bPatterns C to F correspond to ultrasound images indicating various degrees of liver fibrosis attributable to schistosomiasis.
  3. Note: all results are presented as n, or n/n (%), except otherwise mentioned; IQR denotes interquartile range.
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