Extended Data Fig. 1: Similar frequency of severe disease in primary versus secondary cases that were distinguished using stringent IgM/IgG ratios.
From: Severe disease during both primary and secondary dengue virus infections in pediatric populations
Pie charts show the frequency of Severe Dengue (SD), Dengue with warning signs (DW) and Dengue infection without warning signs (DI) cases in primary versus secondary dengue infections that were distinguished using more stringent IgM/IgG ratios indicated on left. The number of patients in each group is indicated below the pie chart. For all three classification methods, the proportion of severe disease was not significantly different between primary and secondary cases (p > 0.78, two-sided Fisher’s exact test). The 95% confidence interval for the percentages indicated in the pie charts are as below: IgM/IgG >1.32, primary: DI- 5.4-11.6, DW-53.4-64.4, SD-27.9-38.5, Secondary: DI- 6.7-13.1, DW-52.8-63.6, SD-27.4-37.6; IgM/IgG >1.4: primary: DI- 5.7-12.1, DW-52.2-63.5, SD-28.5-39.3, secondary: DI- 6.4-12.6, DW-53.8-64.4, SD-26.9-36.9; IgM/IgG >1.78: primary: DI- 5.8-13.0, DW-50.5-62.9, SD-28.7-40.6 and secondary: DI- 6.3-12.0, DW-54.8-64.6, SD-27.0-36.3 (Wilson CI).
