Extended Data Fig. 3: Dengue specific responses in infants (≤1-year-old).
From: Severe disease during both primary and secondary dengue virus infections in pediatric populations
a, Scatter plot shows dengue specific IgM and IgG index values by capture Elisa (Panbio) for dengue confirmed infants (n = 34). p values were calculated using two-sided Mann-Whitney U tests b, Neutralizing antibody titers to the indicated infecting virus serotype in dengue confirmed infants where the infecting serotype was determined (n = 26). c. Scatter plots show dengue specific IgM index values by Panbio Capture ELISA among the infants with different grades of disease severity. Severe dengue (SD, n = 22); Dengue with warning signs (DW, n = 12). Note that there are no Dengue infection without warning signs (DI) cases since all the hospitalized infants were either SD or DW cases. p values (p = 0.087) were calculated using two-sided Mann-Whitney U tests. Non-significant p values (>0.05) are indicated as n.s. d. Scatter plots show neutralizing activity against the indicated infecting dengue virus serotypes among the infants with different grades of disease severity. Severe dengue (SD, n = 15); Dengue with warning signs (DW, n = 11). Note that there are no DI cases since all of the hospitalized infants were either SD or DW cases. p values (p > 0.999) were calculated using two- sided Mann-Whitney U tests. Non-significant p values (>0.05) are indicated as n.s.
