Extended Data Fig. 3: Identification and metabolic-potential profiling of the top 22 response predictive strains.
From: A gut microbial signature for combination immune checkpoint blockade across cancer types
a, Kernel density plot of impact (feature importance) of strains in the strain-RvsP classifier. The top 22 strains with absolute impact within half maximal value shown (coloured by importance, and size by prevalence). b, Strain impact (absolute) versus prevalence in the CA209-538 cohort. Top 22 strains coloured (blue and red for positive and negative associations with response, respectively), with importance threshold depicted (red dashed line). c, Plot of principal coordinate 1 vs 2 using Jaccard dissimilarity of metabolic pathway presence/absence for top 22 strain genomes. Points (individual strains) coloured by impact on RvsP, and size by prevalence. Acronyms: PCo= principle coordinate.
