Extended Data Fig. 2: Correlation of plasma EV Tau ratio with NfL in DESCRIBE cohort 2 and Sant Pau cohort.
From: Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
(a-d) Two-sided Spearman correlation analysis of associations and monotonic regression splines between plasma sEV 3R/4R Tau ratios and plasma Nfl levels in (a) PSP (p = 0.000012) and (b) bvFTD (p = 0.000051) diagnostic groups. Spearman correlation analysis of associations and monotonic regression splines between plasma sEV TDP-43 levels and plasma Nfl levels in (c) ALS (p = 0.000046) and (d) bvFTD (p = 0.000063). (e-g) Sant Pau cohort: Spearman correlation analysis of associations and monotonic regression splines between plasma sEV 3R/4R Tau ratio and plasma Nfl levels in (e) PSP and (f) bvFTD. Spearman correlation analysis of associations and monotonic regression splines between plasma sEV TDP-43 and plasma Nfl levels in (g) bvFTD (p = 0.000085). (NfL measurements were only available for a subset of Sant Pau cases).
