Extended Data Fig. 9: Correlating HLA gene cis-eQTL effects between peripheral immune cell types.
(a) Variants with evidence of being cis-expression quantitative trait modulators are plotted by position across the HLA against evidence of significance of impacting expression of four HLA transcripts. Only variants with significant evidence (P < 5 ×10-8) of association from the meta-analysis of estimates derived from linear regression performed in each population group are coloured by gene, with the remainder of variants coloured in grey. RNA sequence data from lymphoblastoid cell lines from 655 individuals were mapped to personalised HLA gene sequences derived from high-resolution typing. (b) The correlation in P-value estimates for variants predicted to be cis-eQTL variants in different cell types from 80 individuals included in the DICE dataset. 10 of 13 cell types are presented with scatter plots in the lower half of the table and two-tailed Spearman rho estimates in the upper half. Included cells are naïve B-cells, naïve and stimulated (STIM) CD4, and CD8 T-cells, monocytes, natural killer (NK), and follicular helper (TFH), helper-1, and helper-2 T-cells.
