Extended Data Fig. 3: 26-week changes in cognitive test scores by dose group.
Box plots showing the change in score between the first and last assessment on the a) NTB z-score, b) ADAS-Cog-13 (ADAS13), and c) MMSE in the placebo (salmon), 200 mg LM11A-31 (green) and 400 mg LM11A-31 (blue) groups. Note that y axes are scaled differently in each panel. Horizontal lines on box plots represent the median of the distribution. Notches provide 95% confidence intervals of the median. The lower and upper hinges of the boxplot correspond to the first and third quartiles of the distribution, and the whiskers (vertical lines) extend from the hinge to the largest or smallest value, no further than ±1.5 times the interquartile range from the hinge. Kruskal-Wallis tests did not detect a significant difference between the three groups for any cognitive test (PNTB = 0.346; PADAS = 0.964; PMMSE = 0.651). All statistics were performed two-sided and were not adjusted for multiple comparisons, given the exploratory nature of the study. ADAS, ADAS-Cog-13.
